DEVELOPMENT AND GROWTH OF SKELETON. GROWTH CARTILAGE.
ZEMKOVÁ, D., MAŘÍK, I. DEVELOPMENT AND GROWTH OF SKELETON. GROWTH CARTILAGE.. Lublin, 2014.
|Anglický název:||DEVELOPMENT AND GROWTH OF SKELETON. GROWTH CARTILAGE.|
|Autoři:||Daniela Zemková , Doc. MUDr. Ivo Mařík CSc.|
|Abstrakt EN:||New studies suggest that CNP analogues may provide a novel therapeutic approach to growth disorders. Growth hormone produced by the pituitary gland and IGF1 produced by proliferating and hypertrophic chondrocytes, appear to act largely independently to control the rate of chondrocyte proliferation. They appear to be the major regulators of linear bone growth and body size in mammals. Lower expression of IGF1 due to malnutrition and chronic inflammation is the cause of secondary growth failure in number of chronic diseases. Thyroidal hormones also participate in the processes of chondrocyte maturation through wnt signaling. In the past, vitamin D dependent rickets was one of the frequent causes of growth failure. The disorders of calciophosphate metabolism may be congenital or accompanying some chronic diseases. Apart from mentioned genetic, hormonal and metabolic influences, the resulting shape and architecture of the skeleton is determined by intermittent cyclic supraliminal loading that stimulates osteoresorption or osteoformation through RANKL-RANK-OPG pathway (that is coupled to the dual action of tumour growth factor beta -TGF-beta) and by effect of periosteal membrane and perichondrium (in the region of growth plates). The global thickening of the bone tissue includes the sequence of biomechanical-chemical processes (i.e. biochemical reactions and steady states) whose result is the increase of density in the bone tissue. The review is documented on patients diagnosed and in the long term treated in the Ambulant Centre for Defects of Locomotor Apparatus.|